Jeremy Loenneke on Blood Flow Restriction Training, Periodization, General Adaptation Syndrome and HIT

Jeremy Loenneke
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Dr. Jeremy Loenneke is an Assistant Professor of Exercise Science at The University of Mississippi within the School of Applied Sciences. He obtained his PhD in Exercise Physiology from the University of Oklahoma under the mentorship of Dr. Michael Bemben. Dr. Loenneke had previously earned a Master’s degree in Nutrition and Exercise Science from Southeast Missouri State University under the mentorship of Dr. Joe Pujol. His research focuses on skeletal muscle adaptations to exercise with and without the application blood flow restriction.

Contact Jeremy:

In this episode we discuss:

  • The different applications of blood flow restriction training
  • Optimising muscle hypertrophy
  • HIT vs High-Volume exercise
  • Periodization training
  • General Adaptation Syndrome
  • And more!

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Show notes

  • What does Jeremy do? [5:05]
  • Blood flow restriction training – what is it and how does it work? [8:35]
  • What has the research on blood flow restriction taught Jeremy about muscle hypertrophy? [11:20]
  • Does blood flow restriction provide any additional benefit in the context of HIT? [12:40]
  • Where might blood flow restriction be applied for a more efficient resistance training workout? [14:40]
  • How blood flow resistance training might be useful when you’re not “feeling it” before a workout [17:20]
  • Exact blood resistance training protocols for you to try [20:06]
  • Based on the evidence that muscle hypertrophy can be achieved without improvements in strength, should we be less focused on improving strength from workout to workout if our goal is more muscle hypertrophy? [24:25]
  • Methods to optimise muscle hypertrophy [30:45]
  • HIT vs High-Volume exercise [31:50]
  • Why one might require more volume on a big compound exercise to optimise muscle hypertrophy [34:00]
  • What has Jeremy changed his stance on in terms of resistance training in the last few years? [34:55]
  • Is periodisation training necessary for improvements in strength and muscle hypertrophy? [35:55]
  • Is there such a thing as “natural periodisation” where one can experience fluctuations in performance due to hormonal cycles, circadian rhythm and other factors? [41:00]
  • The mystery of delayed onset muscle soreness (DOMS) [43:50]
  • Jeremy’s current training protocol [46:02]
  • Would a competitive powerlifter increase their risk of injury training all year with 1 rep-max [51:15]
  • Jeremy’s upper body circuit [52:28]
  • Jeremy’s diet [54:35]
  • How often does Jeremy practice blood flow restriction training? [55:30]
  • What has Jeremy changed his mind about in the last year regarding health and fitness? [56:25]
  • What does Jeremy believe to be true that almost no one else agrees with him on? [57:30]
  • What does Jeremy believe to be true but can’t currently prove? [1:01:40]
  • Jeremy’s view on the layman consuming scientific literature effectively [1:08:35]
  • Jeremy’s general recommendations on optimising an individuals training regimen to simulate maximum muscle hypertrophy [1:13:10]
  • Jeremy’s contact details [1:16:20]

Selected Links from the Episode

People Mentioned

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  • Jay PH

    Fantastic episode Lawrence

    I enjoyed All his anwsers to your questions , although he did not really anwser the time under load(TUL) part when discussing volume. I wondered what his thoughts about TUL were.


    • Jeremy Loenneke

      Jay, I apologize, what is your specific question?

      • Jay PH


        I am sorry, I do not remember if this question was asked at all and I couldn’t find it while replaying the podcast. Anyway, I was wondering what you think about defining volume in terms of the time a muscle in an exercise is under load(TUL). If you say volume(sets/reps) is important up to a point, would you say the same for the TUL for each muscle group in a workout?

        BTW, loved your view on strength vs size change. I never understood these lifting benchmarks(1RM’s) that you HAVE to achieve for muscle growth and to belong to the bro-club.



  • Thomas

    Dr. Loenneke said the three words (several times) that proves he’s a true scientist: “I don’t know.” It’s always refreshing to here that imo. “It ain’t what you don’t know that gets you into trouble. It’s what you know for sure that just aint so.”-MT